Program

The preliminary program can be found below. Final program will be published here at the beginning of August.

Monday, August 27

09:00 – 19:00

12:00 – 20:00
Participant registration (Ritsumeikan University, Osaka-Ibaraki campus, conference hall desk)

18:00 – 20:00
Welcome dinner (Camping Kitchen)

Tuesday, August 28

09:00 – 09:20
Opening ceremony

PhysChem methods and properties

09:20 – 10:00
Shinji Yamashita , Setsunan University, Japan
PhysChem meets ADME

10:00 – 10:40
Kin Tam, University of Macau, Macau
Spectrophotometric pKa determination of ionizable pharmaceuticals: Resolution of molecules with weak pH-dependent spectral shift

10:40 – 11:00
Coffee break & Poster session

11:00 – 11:40

Alex Avdeef,
in-ADME Research,USA
Capillary Flow Hydrodynamics and Carrier-Mediated Transport of Opioid Derivatives at the BBB: Crone-Renkin-pH and Michaelis-Menten-pH Analyses

11:40 – 12:10
Godefridus Peters, VU University medical center, The Netherlands
Distribution of tyrosine kinase inhibitors in relation to biomimetic properties

12:10 – 12:35
Exhibitors Presentations
 
  Lunch & Poster session

ADME and PK


14:00 – 14:40
Zoran Mandić, University of Zagreb, Croatia
Peculiar pharmacokinetics of macrolides. The role of membrane potential

14:40 – 15:20
Nikoletta Fotaki, University of Bath, UK
Challenges in Physiologically Based Pharmacokinetic Modeling for the Prediction of In vivo Performance After Oral Administration

15:20 – 15:40
Coffee break & Poster presentations

15:40 – 16:20

Masaaki Imono, Shionogi, Japan
Mechanism analysis of oral absorption enhancement of nanocrystal through dissolution-permeation profile (tentative title)

16:20 – 17:00
Asami Ono, AsahiKASEI, Japan
Application of the BCS biowaiver approach to assessing bioequivalence of orally disintegrating tablets with immediate release formulations (tentative title)

17:00 – 17:25
Guillaume Louit, Sanofi R&D, France
Prediction of NCE bioavailbility in Dog based on physicochemical profiling, modeling and confirmation in vivo to prepare first in human studies

17:25 – 18:00
Presentations
 
18:30 – 20:30
Conference dinner: Garden Terrace Lion at Ritsumeikan University, Osaka-Ibaraki campus

Wednesday, August 29

Solid state session 

09:00 – 09:40
Makoto Mukaida, AsahiKASEI, Japan
Validation of in silico model for predicting co-crystal formation using co-crystal former exchange reaction (tentative title)

09:40 – 10:20
Rolf Hilfiker, Solvias, Switzerland
The challenge to find a new viable solid form – From screening to characterization, selection and scale-up

10:20 – 10:40
Coffee break & Poster session

10:40 – 11:20

Katsuhiro Kobayashi
, Daiichi-Sankyo Co., Ltd., Japan
Effective and Convenient Salt & Cocrystal Crystallization Screening Using Water Suspension Method

11:20 – 12:00
Hideomi Kijima, Ono Pharmaceuticals, Japan
Contact Secondary Nucleation and Self Assembled Monolayer

12:00 – 12:40
Daiki Nagamatsu, Shionogi, Japan
Evaluation of the crystallization difficulty of organic compounds using the critical supersaturation ratio (tentative title)
  Lunch & Poster session

14:00 – 20:00

Excursion to Kyoto Arashiyama

Thursday, August 30

Pharma analytical technology session
09:00 – 09:40
Klara Valko, Bio-mimetic chromatography Ltd, UK
Application of biomimetic HPLC to estimate in vivo distribution of new modalities (peptides and macrocycles)
09:40 – 10:20
Konstantin Tsinman, PION, USA
In Vivo Predictive Dissolution – Flux Measurements

10:20 – 10:50
Coffee break & Poster session

10:50 – 11:30

PION
, USA
Innovative In Situ Measuring Tools for Formulation Development

11:30 – 12:10
Alex Avdeef, in-ADME Research, USA
Ksp of Drug Salts and Cocrystals: Simulations to Improve Design of Experiments According to the Interlaboratory Consensus Recommendations

12:10 - 13:30
 
Lunch and Poster presentations
 
 Special session: Supersaturating DDS

13:30 – 14:10
 
Patrick Augustijns, University of Leuven, Belgium)
In-vivo gastrointestinal supersaturation in humans
14:10 – 14:50
Shunsuke Osaki, Eisai,Japan
Kinetic analysis of crystallization for the prediction of drug supersaturation behavior
14:50 – 15:20
Coffee break & Poster session
15:20 – 16:00
Shou-Cang Shen, Institute of Chemical and Engineering Sciences, Singapore
Mesoporous Excipients for Effective Delivery of Poorly Soluble Drugs

15:40 – 16:20
Abu Serajuddin, St. John University,USA
Development of Supersaturating Solid Dispersions of Poorly Water-Soluble Basic Drugs by Interaction with Non-Salt Forming Weak Carboxylic Acids and with HPMC-AS
16:20 – 17:00
Hikaru Sugihara, Ono Pharmaceuticals,Japan
Evaluation of Supersaturation Behavior of Pazopanib Hydrochloride in the Presence of HPMC by pH-Shift Dissolution Testing

 17:00 Conference closing

 

 

Copyright 2009 IAPC