Friday, September 20th
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09:00 – 10:00
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Participant registration, Conference Hall, Hotel Princess Royal
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10:00 – 10:15
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Summer school opening
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10:15 – 13:00
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Mario Grassi, Trieste University, Italy, Determination of nanocrystals size distribution in polymer-drug systems
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| Lunch | |
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15:00 – 16.50
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John Comer, Sirius Analytical Ltd., UK, Overview of physicochemical profiling. Biopharmaceutical Classification System (BCS), ionization (pKa), lipophilicity (logP), and solubility (S0, Sw, Sbuf). Effects of pH.
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| 16:50 - 17:15 | Cofffe break |
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17:15 - 19:00
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Alex Avdeef, in-ADME Research, USA, Salt Solubility and Solubility Product (Ksp) measurement -new perspectives in support of salt selection
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Saturday, September 21st
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09:00 – 10:45
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Sven Frokjaer, University of Copenhage, Denmark, Formulation Development of Peptides and Proteins
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| 10:45 - 11:15 | Coffee break |
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11:15 – 13:00
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Biserka Cetina Čižmek, Pliva Ltd, Croatia, Analytical methodologies in the formulation development
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| Lunch | |
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15:00 – 16.45
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Alex Avdeef, in-ADME Research, USA, Drug inestinal absorption and permeability. Artifical membrane (PAMPA) and cell-based models (Caco-2/MDCK) - effects of pH. Passive property prediction.
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| 16:45 - 17:15 | Cofffe break |
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17:15 – 18:00
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Alex Avdeef, in-ADME Research, USA, Blood-brain barrier (BBB) penetration and permeability. IVIV correlations between in vitro brain microcapillary endothelial cell (BMEC) models and rodent in situ brain perfusion drug uptake. Artifical membrane (PAMPA-BBB). A novel in silico brain penetration classification (BPC) prediction model.
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| 18:10 – 19:00 | Biserka Cetina Čižmek, Pliva Ltd, Croatia, Excipients and their compatibility |
Sunday, September 22nd
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09:00 – 10:45
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Rolf Hilfiker, Solvias AG, Switzerland, Co-Crystals: The importance of choosing the optimal solid form of drug. Salts, co-crystals, polymorphs and solvates. Part 1.
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| 10:45 - 11:15 | Coffee break |
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11:15 – 13:00
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Rolf Hilfiker, Solvias AG, Switzerland, Co-Crystals: The importance of choosing the optimal solid form of drug. Salts, co-crystals, polymorphs and solvates. Part 2.
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| Lunch | |
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15:00 – 16.45
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Christos Reppas, National and Kapodistrian Collaborators of Athens, Greece, Choosing the optimal oral dosage form.
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| 16:45 - 17:15 | Cofffe break |
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17:15 – 19:00
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Christos Reppas, National and Kapodistrian Collaborators of Athens, Greece, In vitro performance testing of orally administred drug products: Case studies.
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| 20:00 – | Welcome party, joint ESSFD-1 and PCMDDD-3 event, Taraca Lounge bar |