Special Session on the ADME properties and toxicity prediction by HPLC

“Application of lipophilicity, protein and phospholipid binding measured by HPLC for prediction of ADME properties and toxicity of compounds”

Session chair: Klara Valko (Biomimetic chromatography, Ltd., UK)

HPLC provides an excellent tool for measuring the compound’s properties and determining the in vivo distribution. Using biomimetic stationary phases, such as human serum albumin, glycoprotein, immobilized artificial membrane, or reversed phase with various micelles in the mobile phase, can model the compound’s biological distribution. The volume of distribution, blood/brain barrier distribution, cellular concentration, drug efficiency, skin penetration, aquatic toxicity, hERG inhibition, and phospholipidosis, among others, can be estimated using the measured properties. In this session, invited speakers who published significant contributions to the field will exchange ideas.

The exact schedule can be found on the Program page.

The list of speakers and tentative topics can be found below (the list will be continuously updated).

Speakers:

- Klara Valko (Biomimetic chromatography, UK): Application of lipophilicity, protein and phospholipid binding measured by HPLC for prediction of ADME properties and toxicity of compounds
- Giulia Caron (University of Turin, Italy): The love story of physchem data and oral bioavailable bRo5 drug candidates
- Laurence Philippe-Venec (PIC Analytics, USA): Chromatography to highlight compounds behavior in a membrane: a journey of interactions
- Giacomo Russo (Edinburgh University, Scotland): From delta log kwIAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?
- Chrysanthos Stergiopoulos (University of Athens, Greece): Application of biomimetic chromatography for the prediction of acute aquatic toxicity of organic pollutants