ESSFD-1 Lecturers

Alex Avdeef, In-ADME Research,USA
Alex is an internationally-known authority on solution chemistry, with outstanding academic credentials and an extensive list of publications (110 technical publications in primary scientific journals & chapters in books, 6 patents and over 300 invited lectures). For over 40 years, he has been teaching, researching, & developing methods, instruments, & analysis software for measurement of ionization constants (pKa), solubility (practically-insoluble molecules), dissolution (small-volume, mechanistic, pH-dependent), & permeability (pH-dependent PAMPA, cell-culture, & animal models). He founded (2011) in-ADME Research (USA) and co-founded pION INC (USA) in 1996 & Sirius Analytical (UK) in 1989. He is the author of Absorption and Drug Development, Second Edition, Wiley, Hoboken, 2012. His accomplishments in the development of instrumentation include several well-known instruments currently manufactured by leading companies in the instrument market (e.g., ORION960 Autochemistry System - Launched in 1984 and still being sold by ThermoFisher today). In the rich career he took several position in academic and industrial settings (pION INC (USA), SIRIUS ANALYTICAL (UK), ORION RESEARCH (USA), SYRACUSE UNIVERSITY (USA), CAL BERKELEY "go Bears" (USA), & CALTECH (PASADENA, USA)).
Biserka Cetina-Čižmek , PLIVA, Croatia
Biserka has been working in GR&D PLIVA pharmaceutical company in Croatia, member of Teva group for last twelve years. Her current position is Senior Director and head of Preformulation Department. She is pharmacist by education. She finished Ph.D. in Pharmaceutical Sciencie and worked as Senior Lecturer in field Pharmaceutical Analysis and since 2007 she has become Professor in the field of Pharmaceutical sciences at Faculty of Pharmacy and Biochemistry University of Zagreb. Her scientific background is the field of preformulation studies in drug development of solid dosage forms, semisolid and liquid, development of in vitro methodology to predict in vivo drug behavior, IVIV correlation, characterization of drug molecules, and BCS classification. She is author and co-author of 30 scientific papers, 47 posters and 12 oral presentations, 3 patent applications and mentor of 22 graduated and 3 postgraduate students.
John Comer, Sirius Analytical Ltd. UK
John is Chief Scientific Officer of Sirius, and one of the founders of the company. The company started in 1989 after he found there was no instrument on the market to measure pKa values of drugs, and scientists had great difficulty in measuring them. Prior to Sirius John worked for two other instrument companies, providing applications support to customers and sales staff. This experience involved a great deal of travel and he has visited laboratories in many countries, which has been of great value for understanding scientists’ needs and for the specification and development of new instruments. John has remained focused on the science that underlies the measurement of drug physicochemical properties, with a list of 45 related publications.
Sven Frokjaer, University of Copenhagen, Denmark
Sven received his M.S. (Pharm.) in 1970 and his Ph.D. in physical chemistry in 1973 from the Danish University of Pharmaceutical Sciences. He has been Professor of pharmaceutics at the Department of Pharmaceutics since 1993, and Rector at the Danish University of Pharmaceutical Sciences from 2003 to 2007. After the merge with the University of Copenhagen he became Dean at the Faculty of Pharmaceutical Sciences. Since 2012 he is Vice-Dean at the Faculty of Health and Medical Science, University of Copenhagen. From 2002 to 2005 he held the position was director of the industrial oriented graduate research school “Drug Research Academy” where he his is now chairman of the board. Before joining the university, Sven Frokjaer spent nearly 20 years at Novo Nordisk A/S where he was involved in research on drug delivery systems and various aspects of peptide and protein formulation.  Today, his primary research interest is focussed on peptide and protein formulation with a special emphasis on particulate drug delivery systems, e.g. microspheres, liposomes and lipid emulsions, and peptide transport across biological membranes including carrier-mediated mechanisms. He has published more 120 scientific papers in these fields. Sven Frokjaer is a member of several boards and committees including The Danish Pharmacopeia Commission and the Drug Registration Committee under The Danish Medicines Agency. He serves as member of editorial boards on several pharmaceutical journals He has also served as member at the Danish Medical Research Council for a period of 5 years. Sven Frokjaer is co-founder of two biotech companies, Lica Pharmaceuticals A/S and LiPlasome Pharma A/S.
Mario Grassi Hobby Building Tips, University of Trieste, Italy
Mario got his five years graduate degree in Chemical Engineering on April 10th (110/110 cum laude) at the Trieste University defending a thesis entitled “Study on diffusion in biopolymeric hydrogels for the designing of pharmaceutical controlled release systems”. He got his Ph.D. degree in Chemical Engineering at the Padova University (Italy) on December 13rd 1996 defending a thesis on “Drug diffusion in polymeric gel matrices used in the pharmaceutical field”. He got a one-year grant (1996) from the Physical Pharmacy Laboratory of Vectorpharma Trieste (pharmaceutical industry dealing with the improvement of poorly bioavailable drug) in order to study diffusion processes and drug activation by means of mechano-chemical activation. He got a Post Doct. grant (December 12th 1996 - December 12th 1998) from the Department of Chemical Engineering (DICAMP) (Trieste University) in order to study from an experimental and theoretical view point drug diffusion in polymeric matrices and release processes. Particular care was devoted to the study of viscoelastic and rheological properties of polymeric systems. He got a four years grant (Assegno di ricerca - Research check) (January 25th 1999 - January 25th 2002) at the Department of Chemical, Environmental and Raw Materials Engineering in order to experimentally and theoretically studying drug release process from different kinds of release systems (polymeric matrices and mini-matrices). The attention was focused on mass transport, thermodynamic and the relation existing among mass diffusion and rheological characteristics of the polymeric network. 2002-2004 he has been employee of EURAND (Pharmaceutical Industry dealing with the improvement of poorly bioavailable drugs) as co-ordinator of the Trieste site research activities. On November 19th 2005 he became associate professor at the Faculty of Engineering of the Trieste University teaching “Macromolecular Materials Engineering", “Diffusive processes in complex media”, “Principles of Tissue Engineering and Biomaterials” and “Process simulation”. He is author or co-author of more than 90 papers in international journals and more than 150 congress communications. He is co-authors of a book entitled: “Understanding drug release and absorption mechanisms: a physical and mathematical approach” M. Grassi, G. Grassi, R. Lapasin I. Colombo. CRC Press, BocaRaton (USA). 2007, 1-627, ISBN 0 8493 3087 4. At present his research field is about a) modeling of drug release from delivery systems and drug absorption by living tissues b) characterization of delivery systems (polymer based) and drug for what concerns nano-crystals peculiar properties.
Rolf Hilfiker, Solvias AG, Switzerland
Rolf is Vice President and Head of the Department Solid-State Development at Solvias AG. Solvias AG is a scientific services company focused on leveraging expertise in various scientific disciplines to accelerate the drug discovery and development process. The department of some 25 people does contract research and development in the solid-state area, i.e. polymorphism studies, crystallization optimization, etc. Rolf obtained his Ph.D at the University of Basel, Switzerland. From 1987-89 he was Post Doc at SUNY, New York and from 1989-1992 Senior Research Fellow at the University of Basel. He has more than fifteen years of experience in an industrial R&D environment at Ciba-Geigy, Novartis, and Solvias. In the last 9 years he has substantially expanded the solid-state department.
Christos Reppas, University of Athens, Greece
Christos is Professor of Pharmaceutics, Faculty of Pharmacy, National and Kapodistrian (N&K) University of Athens, Greece. He received his B. Pharm degree in Pharmacy from the N&K University in Athens in 1982 and his Ph.D in 1986 from the same University. From 1988 to 1989 he completed a postdoctoral fellowship in Pharmaceutics at the University of Michigan (USA) and then he joined the N&K University of Athens in 1989 as a Lecturer. He has held research positions with the University of London (UK), the University of Michigan (USA), Glaxo R&D (UK) and the University of Frankfurt (Germany). Research interests focus on the effects of gastrointestinal physiology on intralumenal performance of xenobiotics and the development of in vitro tests that are predictive of the intralumenal dosage form and drug performance. He is coauthor of more than 80 peer reviewed papers in international journals, two books and one patent.