IAPC-4 Plenary Lectures & Program

Sunday, September 20th

15:00 – 19:30
Participant registration

20:00 –
Welcome party

Monday, September 21st

08:00 – 09:00
Poster mounting

09:00 – 09:15
Opening ceremony

09:15 – 10:00
Peter Krajcsi, Solvo Biotechnology, Hungary
Models and methods to study drug transport accross barriers

10:00 – 10:45
Klara Valko, GSK, UK
Physicochemical and biomimetic properties to guide lead optimization to improve in vivo efficacy

10:45 – 11:15
Coffee break
11:15 – 11:50
Konstantin Tsinman, pION, USA
Studying Interplay of Dissolution, Solubility and Permeability in Formulation Development using In Situ Concentration Monitoring

11:50 – 12:25
Antonio Llinàs, Rebeca Ruiz, John Comer, Sirius Analytical Ltd., UK
The measurement of physicochemical properties of orally inhaled drugs at 37 °C in Simulated Lung Fluid – methods and formulations

12:25 – 13:00
Martí Rosés, Elisabet Fuguet, Joan Marc Cabot, University of Barcelona, Spain
Determination of the acidity of poorly water-soluble drugs by the Internal Standard - Capillary Electrophoresis method

15:00 – 15:45
Abu Serajuddin, St. John’s University, USA
Strategies for the development of liquid, semisolid and solid lipid-based drug delivery systems

15:45 – 16:30
Christos Reppas, University of Athens, Greece
Predictive in vitro tests for locally acting oral medicinal products?

16:30 – 17:00
Coffee break

17:00 – 17:35

Josef Jampilek,
Aneta Cernikova, Katarina Tabiova, Pavel Bobal, University of Veterinary and Pharmaceutical Sciences, Czech Republic
In vitro evaluation of 8- substituted 6,9-diazaspiro[4.5]decan-7,10-diones as skin permeation modifiers

17:35 – 18:10
Jasmina Lovrić, University of Zagreb, Croatia
Early biopharmaceutical characterization to predict eye-related bioavailability

18:10 – 18:30
Vesna S. Živanović, Miloš P. Pešić, Viola Horváth, János Madarász, Ilija N. Cvijetić, Gordana V. Popović, Tatjana Ž. Verbić, Alex Avdeef, University of Belgrade, Serbia
Terfenadine solubility studies

Monday, September 21st - Speical solubility session

20:30 – 20:50
Alex Avdeef, in- ADME Research, USA
Data Mining for Equilibrium (Non-Amorphous) Solubility of Druglike Molecules

20:50 – 21:10
Krisztina Takács-Novák, Gergely Völgyi,Semmelweis University, Hungary
Best practices for saturation shake-flask measurements of thermodynamic solubility

21:00 – 21:30
Elisabet Fuguet, Elham Shoghi, Elisabeth Bosch, Clara Ràfols,University of Barcelona, Spain
Solubility–pH profiles of some drugs determined by the shake-flask method

21:30 – 21:50
Antonio Llinàs, AstraZeneca R&D, Sweden
The solubility challenge

Tuesday, September 22nd

09:00 – 09:45
Hong Wan, Shanghai Hengrui Pharmaceutical, China
Antibody-drug conjugate (ADC) drug development from ADME perspectives

09:45 – 10:20
Ta-Chau Chang, National Taiwan University, Taiwan
Molecular imaging of fluorescent ligand-DNA interaction in live cells for guiding the development of anti-cancer agents

10:20 – 10:50
Csaba Hetényi, Norbert Jeszenői, Mónika Bálint, David van der Spoel, István Horváth, Hungarian Academy of Sciences, Hungary
Dynamic prediction of hydration structures of biomolecular complexes

10:50 – 11:15
Coffee break

11:15 – 11:50

Godefridus J. Peters,
R.J. Honeywell, VU University Medical Center, The Netherlands
The role of uptake, cellular or tissue distribution, and the target on the efficacy of tyrosine kinase inhibitors

11:50 – 12:25
Kin Tam, Wei Zhou, Ken Yung, Ricky Wong, Hung Wing Li, Unviersity of Macau, Macau
Permeability assessment and pharmacokinetics of some β-amyloid aggregation inhibitors for the treatment of Alzheimer’s disease

12:25 – 13:00
Yin Tian, Zechao Ding, Zhongyan Wang, Huiling Zhang, ChongQing University of Posts and Telecommunications, China
The predictors of drug effects on Alzheimer’s disease: shed new light from EEG parameters to brain connectomics

15:00 – 15:40
Ernest Meštrović, Pliva Croatia Ltd., Croatia
The role of Material Science in the Research and Development of Drug Substance and Drug Product

15:40 – 16:20
Elena Boldyreva, Novosibirsk State University, Russia
Non-ambient conditions in drug forms discovery and development

16:20 – 16:40
Marzena Rams-Baron, Zaneta Wojnarowska, Mateusz Dulski, Katarzyna Grzybowska, Justyna Knapik, Marian Paluch, University of Silesia, Poland
The impact of molecular mobility and molecular interaction patterns on physical stability of amorphous anti-inflammatory agents

16:40 – 17:00
Coffee break
17:00 – 17:45
Rolf Hilfiker, Solvias AG, Switzerland
Quantification of Amorphous Content in Drug Substance and Drug Product

17:45 – 18:15
Biljana Janković, Stane Srčič, University of Ljubljana, Slovenia
Quantitative mechanical measurements at the nano-scale for the crystalline pharmaceutical ingredients

18:15 – 18:30
Marian Paluch, Karolina Adrjanowicz, University of Silesia, Poland
Toward Better Understanding of Crystallization of Amorphous Drugs under Compression: Isochronal Crystallization Kinetics Approach

18:30 – 18:45
Tamás Sovány, Barbara Sipos, Zoltán Kónya, Klára Pintye-Hódi, Géza Regdon jr, University of Szeged, Hungary
Application of titanate nanotube composites for the modification of the solubility, dissolution kinetic and processability of drugs

18:45 – 23:00
Poster session

Wednesday, September 23rd

08:00 – 09:00
Poster dismounting

09:00 – 09:45
Uko Maran, Sulev Sild, Villu Ruusmann, Geven Piir, Alfonso T. García-Sosa, Kalev Takkis, Mare Oja, Elmar Laigna, Priit Ahte, Iiris Kahn, Andre Lomaka, University of Tartu, Estonia
QsarDB: chemo-informatics solution for preserving and efficient use of in silico physicochemical, toxicological, biochemical and human health endpoint models

09:45 – 10:30
Michael B. Bolger, Viera Lukacova, James M. Mullin, Ke Xu-Szeto, Simulations Plus Inc., USA
Simulation of in vitro Caco-2 Papp from Molecular Structure (Kubinyi vs. QSAR) and Estimation of Intracellular Km for Efflux Transporters

10:30 – 11:00
Coffee break

11:00 – 11:35

Łukasz Pałkowski,
Jerzy Błaszczyński, Andrzej Skrzypczak, Jan Błaszczak, Alicja Nowaczyk, Roman Słowiński, Jerzy Krysiński, Nicolaus Copernicus University, Poland
Structure-activity relationship analysis of new antipseudomonal gemini-imidazolium chlorides

11:35 – 12:10
Mario Grassi, Samuel Golob, Fabio Pontelli, Michela Abrami, Gianluca Chiarappa, Gabriele Grassi, Beatrice Perissutti, Dario Voinovich, University of Trieste, Italy
Antibacterial drug release from a biphasic polymeric system: mathematical modelling

12:10 – 12:40
Ena Melvan, Antonio Starčević, Jurica Zucko, Mario Cindirić, Ivo Ugrina, Daslav Hranueli, University of Zagreb, Croatia
The importance of mathematics in proteomics sequencing

14:00 Excursion and Conference dinner

Thursday, September 24th - joint PCMDDD-4 and Met4pharm session

10:00 – 10:45
Cristina Daolio, Bruker BioSpin GmbH, Germany
LC-SPE-(cryo)NMR/MS as routine analysis technique

10:45 – 11:30
Janez Plavec, National Institute of Chemistry, Slovenia
Exploration of tetrahelical DNA structures as dynamic drug targets by NMR

11:30 – 12:00
Coffee break

12:00 – 12:45

Kevin Embery,
AstraZeneca R&D, UK
The Application of NMR within Drug Discovery: Overview and Case Studies

12:45 – 13:30
Tomislav Biljan, Pliva Croatia Ltd., Croatia
Fluorine NMR in pharma development: from drug substance to drug product

13:30 Conference closing