IAPC-5 Plenary Lectures & Program

The whole event will take place in the Zhuhai Dehan Hotel (Guo Cui, 4/F). Final program of the conference can be found below.  

Monday, August 22nd 2016
15:00 – 19:00 Participant registration / Poster mounting
19:30 – Welcome party – Dehan hotel
Tuesday, August 23th 2016
08:00 – 08:30 Participant registration / Poster mounting
08:30 – 08:45 Opening ceremony
Session 1. Recent advances in the physico-chemical/activity profiling of drug substances
08:45 - 9:30 Jin Li, Hitgen Ltd., China
Finding needles in very large haystacks: DNA-encoded libraries (DELs) for lead generation
9:30 – 10:15 Godefridus J Peters, VU University Medical Center, The Netherlands
Role of physico-chemical and ADME properties in cancer drug development
10:15 – 10:45 Coffee break / Poster session
10:45 – 11:30 Kwok-Yin Wong, The Hong Kong Polytechnic University, China
Development of Fluorescent Biosensors for Screening of Inhibitors of Some Bacterial Enzymes
11:30 – 12:15 Wei Gao, Tonglei Li, Purdue University, USA
Development of Drug Nanocrystals for Theranostics
12:15 – 12:40 Caroline Alvebratt, Erik Petersson, Maria Strömme, Christel A.S. Bergström, Uppsala University, Sweden
A small scale method to determine release rate from complex carrier-mediated systems
Session 2. Recent advances in solid state characterization
14:30 – 15:15 Rolf Hilfiker, Solvias AG, Switerland
Impact of Polymorphism on the Development and Manufacturing of Pharmaceuticals
15:15 – 16:00 Alex Avdeef, in-ADME Research, USA
Cocrystal Solubility-pH Data Analysis using pDISOL-X (with Automatic Equilibrium Equation Generation)
16:00 – 16:20 Shichao Du, Yan Wang, Jingkang Wang, Junbo Gong, Tianjin University, China
Two Novel Cocrystals with Improved Solubility and In Situ Monitoring of Cocrystallization of Lamotrigine 
16:20 – 16:50 Coffee break / Poster session
16:50 – 17:35 Elena Boldyreva, Novosibirsk state university, Russia
Drugs as materials: processing, structure, properties
17:35 – 18:05 Marzena Rams-Baron, Żaneta Wojnarowska, Mateusz Dulski, Patryk Włodarczyk, Marian Paluch, University of Silesia, Poland
The importance of proton transfer in amorphous active pharmaceutical ingredients
18:05 – 18:30 Khadijah Edueng; Denny Mahlin; Christel Bergström, Uppsala University, Sweden
Mechanism-based Selection of Stabilization Strategy for Amorphous Formulation
19:30 - Conference dinner / Dehan hotel
Wednesday, August 24th 2016
Session 3. Recent advances in drug discovery
08:30 – 09:15 Hong Wan, Shanghai Hengrui Pharmaceutical CO., LTD, China
Discovery and Development of Pyrotinib: a Novel Irreversible EGFR/HER2 Dual Tyrosine Kinase Inhibitor with Favorable Safety Profiles for the Treatment of Breast Cancer
09:15 – 09:45 Lihua Tan, Cailan Li, Hanbin Chen, Zhizhun Mo, Jiangtao Zhou, Yuhong Liu, Zhilin Ma, Yuyao Xu, Xiaobo Yang, and Jianhui Xie, Ziren Su, Guangzhou University of Chinese Medicine, China
Epiberberine, a natural protoberberine alkaloid, inhibit urease of Helicobacter pylori and jack bean via binding to the sulfhydryl groups
09:45 – 10:15 Wen Zhang, Xiaohui Hu, Shao-Lin Zhang, Kin Yip Tam, University of Macau, Macau
Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effects
10:15 – 10:45 Coffee break / Poster session
10:45 – 11:30 Tao Chen, Bo Jiang, Yuan Xu, Feng Zhi, Yiling Yang, Ying Xia, The University of Texas McGovern Medical School, USA
A Potential Target for Parkinsonism Treatment
11:30 – 12:15 Wen-Ying Liao, Chih-Chuang Liaw, Chien-Shu Chen, Sheng-Chu Kuo, Yuan-Chao Huang, and Chia-Ning Shen, Genomis Research Center, Academia Sinica, Taiwan
Excessive porphyrin production induced by cyclohexylmethyl flavonoids suppresses self-renewal propagation of breast cancer stem cells
12:15 - 12:40 Li Yang, Zhongyan Wang, Huiling Zhang, Wei Xu, Shuxing Zheng, Haiyong Zhang, Yin Tian, Chong Qing University of Posts and Telecommunications, China
Predictors for drug effects with Alzheimer’s disease: shed new light from EEG parameters to brain connectomics
Session 4. Recent advances in computational methods/modeling, biophysical and analytical techniques of importance in medicinal chemistry and pharmaceutical research
14:30 – 15:15 Alex Avdeef, in-ADME Research, USA
Data Mining for Equilibrium Solubility of Ionizable Druglike Molecules
15:15 – 16:00 Klara Valko, Bio-Mimetic Chromatography, UK
How to optimize the physicochemical and biomimetic properties of putative drug molecules?
16:00 – 16:30 Mare Oja, Uko Maran, University of Tartu, Estonia
Comparison and modelling of experimental and calculated distribution coefficient (logD) values at various pH-s
16:30 – 17:00 Coffee break / Poster session 
17:00 – 17:35 Muhammad Arba, Rahmad Sutrisna, Ruslin, Universitas Halu Oleo, Indonesia
Quantitative structure activity relationship (QSAR) analysis of Indirubin derivatives as cyclin dependent kinase 5 (CDK5) inhibitor
17:35 – 18:10 Ruslin, Rahmad Sutrisna, Muhammad Arba, Universitas Halu Oleo, Indonesia
Design and molecular docking study of novel Indirubin derivatives as inhibitor of cyclin dependent kinase 5 (CDK5)
18:10 - 18:30 Poster dismounting
Thursday, August 25th 2016
Session 5. Recent advances in drug development
09:00 – 09:45 Abu T.M. Serajuddin, St. John’s University, USA
Strategies for the development of liquid, semisolid and solid lipid-based drug delivery systems
09:45 – 10:30 Marian Paluch and Justyna Knapik, University of Silesia, Poland
Study on effective methods for stabilizing the amorphous forms of of anti-cholesterol drug: Ezetimibe
10:30 – 11:00 Coffee break
11:00 – 11:45 Kiyhiko Sugano, Toho University, Japan
Theoretical investigation on bioequivalence and biowaiver scheme
11:45 – 12:30 Shun Ming Yuen, Jie Ye, Gillian Murphy, Ruiyu Xie and Hang Fai Kwok, University of Macau, Macau
Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo
12:30 Conference closing
14:00 Optional excursion: Zhuhai sightseeing tour and dinner


Friday, August 26th 2016
08:30 – 18:00 Post-conference course: Short introduction in drug development