IAPC-2 Plenary Lectures & Program

Sunday, September 18, 2011.
10:00-12:00 Courses 1, 2 and 3
15:00 Registration desk open, Hotel Donat
16:00-18:00 Courses 1, 2 and 3 continuation
20:00 - Welcome party
Monday, September 19, 2011.
09:00-09:20 Opening ceremony
09:20-10:05 The importance and different approaches for the determination of permeability across an artificial membrane, Kin Y. Tam, AstraZeneca, UK

Mechanistic prediction of oral drug absorption from physicochemical property, Kiyohiko Sugano, Pfizer, UK

10:50-11:10 Coffee break
11:10-11:55 Applications of bio-mimetic HPLC methods for the estimation of in vivo distribution of early drug discovery compounds, Klara Valko, GlaxoSmithKline, UK
11:55-12:30 Implementation of In Vitro Permeability Studies for Evaulation and Improvement of Generic Drug Formulations Before Bioequivalence Studies, Seval Korkmaz, Abdi Ibrahim, Turkey
12:30-13:00 Dynamic dissolution testing in R&D, Martin Čulen, Jiri Dohnal, Josef Jampilek, Anna Rezacova, Universiy of Veterinary and Pharmaceutical Sciences, Czech Republic
13:00-15:00 Lunch
15:00-15:40 GLP determination of equilibrium solubility with special interest of ionization and polymorphism, Krisztina Takács-Novák, Semmelweis University, Hungary 
15:40-16:20 Techniques for investigating supersaturation and the enhancement of solubility, John Comer, Sirius-analytical Ltd. UK 
16:20-16:45 Dissolution of nanocrystalline particles for IV route: in vitro studies and in silico modelling, Guillaume Louit, Xavier Pepin, Morgane Vacher, Sanofi-Aventis, France
16:45-17:00 Coffee break
17:00-17:40 Structure-based QSAR studies on 5-HT2A partial agonists, Stefan Dove, Maria E. Silva, Ralf Heim, Andrea Strasser, Sigurd Elz, University of Regensburg, Germany 
17:40-18:20 Modeling Biorelevant Solubility and Dissolution: Effects of Molecular Ionization, Michael B. Bolger, Robert Fraczkiewcz, Marvin Waldman, Dechuan Zhuang, and Walter S. Woltosz, Simulations plus Inc. USA 
18:20-18:45 The relationship study of Clog P and aphicidal activity of cyantraniliprole analogs, HuiBin Yang, Hua Chen, JunFeng Wang, Bin Li, Shenyang Research Institute, China 
18:45-19:10 IS-CE: A fast high-throughput method for pKa determination by capillary electrophoresis, Martí Rosés, Joan Marc Cabot, Elisabet Fuguet, Clara Ràfols, University of Barcelona, Spain


Tuesday, September 20, 2011.
09:00-09:40 NMR studies of peptides and proteins and their interactions: implications for drug development, Horst Kessler, Technical Unversiy of München, Germany
09:40-10:20 Functional mechanisms of drugs studied by NMR: methodology and applications Teresa Carlomagno, EMBL, Germany
10:20-10:50 Determining the orientation of drugs in receptors by solvent paramagnetic relaxation NMR spectroscopy, Simone Kosol, Christoph Göbl, Katarina Culjak, Walter Hohlweg, Predrag Novak and Klaus Zangger, Universiy of Graz, Austria
10:50-11:10 Coffee break
11:10-11:50 The importance in drug design of resolving structural and dynamic details for membrane drug targets at the nanoscale, Anthony Watts, Oxford University, UK
11:50-12:30 Statistically optimized Raman microscopy for detecting low levels of undesired polymorphic forms in low dose active tablets, Slobodan Šašić, Mark Whitlock and Shawn Mehrens, Pfizer, USA
12:30-13:00 14N NQR study of polymorphism of piroxicam and nifedipine; characterization of their polymorphs and solid-solid transformations, Zoran Lavrič, Janez Pirnat, Janko Lužnik, Zvonko Trontelj, Stane Srčič, University of Ljubljana, Slovenia
13:00-15:00 Lunch
15:00-15:40 Challenging characterization of polyphasic drugs. Use of combined physicochemical techniques in pharmaceutical development, Danielle Giron, Consultant, France
15:40-16:20 Hydrates: Thermodynamics and Determination of Relevant Parameters, Rolf Hilfiker, Solvias AG, Switzerland
16:20-16:40 The determination of dehydratation mechanism of lactose monohydrate by using thermogravimetric methods, Petar Tudja, Ernest Meštrović, PLIVA d.o.o, Croatia
16:40-17:00 Coffee break
17:00-17:40 Solid-state chemistry and new drug forms, Elena V. Boldyreva, Novosibirsk State University, Russia
17:40-18:10 Study of the Role of Molecular Mobility in Physical Stability of Amorphous of Anti-Inflamantory Drug: Celecoxib, Marian Paluch, Katarzyna Grzybowska, Żaneta Wojnarowska and Kia L. Ngai, Institute of Physics, Poland
18:10-18:30 Tailor-made batch crystallisation of Entacapone through the use of self-assembled layers on gold single crystal surface, Ana Kwokal, Kevin J. Roberts, PLIVA d.o.o. Croatia
18:30-18:50 Physical insight into tautomerization reaction in some pharmaceutically important molecules, Zaneta Wojnarowska, Marian Paluch, Institute of Physics, Poland
19:00-23:00 Poster session


Wednesday, September 21, 2011
09:00-09:45 The influence of glycosylation to biological activity of proteins, Jasna Peter Katalinić, University of Münster, Germany
09:45-10:30 Mass spectrometric approaches for structural elucidation of “misfolding” - aggregating neurodegenerative proteins: Ion mobility- MS and affinity- MS, Camelia Vlad, Claudia Cozma, Marilena Manea, Marius Iurascu, Kathrin Lindner, Jieun Jung, Martin Scheffner, Marcel Leist, and Michael Przybylski, University of Konstanz, Germany
10:30-10:50 Coffee break
10:50-11:35 Biophysical methods for identifying and characterizing protein-ligand interactions, Geoff Holdgate, AstraZeneca, UK
11:35-12:00 Dynamic Force Spectroscopy for studying high affinity ligand receptor complexes, Pierre Parot and Jean-Luc Pellequer, CEA Marcoule, France
12:00-12:25 TRANSIL High Sensitivity Binding Assay: A novel tool for assessing plasma binding of hardly soluble and sticky drugs, Hinnerk Boriss, Sovicell GmbH, Germany
12:25-13:30 Lunch
13:30-19:30 Excursion
20:30- Social dinner


Thursday, September 22, 2011.
09:00-09:45 Chromatographic and spectroscopic studies on the chiral recognition of sulfated β-cyclodextrin as chiral mobile phase additive: Enantiomeric separation of a chiral amine, Shengli Ma, Sherry Shen, Nizar Haddad,Wenjun Tang, JingWang, Heewon Lee, Nathan Yee, Chris Senanayake, Nelu Grinberg, Boehringer-Ingelheim, USA
09:45-10:30 Automated Patch Clamp in Drug Discovery – from the bench to the midfield, Morten Sunesen, Sophion Bioscience, Denmark
10:30-10:50 Coffee break
10:50-11:15 Synergistic and antagonistic effects between selected phenolic and polyphenolic antioxidants, Ewelina Kowalewska, Grzegorz Litwinienko, University of Warsaw, Poland
11:15-11:40 Compressibility investigation of chewing gum bases used for API containing direct compressed chewing gum tablet preparation, Peter Kasa jr., Imre Jojart, Klara-Pintye Hodi, University of Szeged, Hungary
11:40-12:05 Dynamics of enzymes-inhibitor complexes from protein crystallography, J. Hašek, K. Zimmerman, T. Skálová, J. Dušková, J. Dohnálek, Institute of Macromolecular Chemistry, Czech Republic
12:05- Seminar/Workshop: Bioaffinity - Mass Spectrometry, Michael Przybylski, University of Konstanz, Germany
13:00 Conference closing